Perhaps, [O Muhammad], you would kill yourself with grief that they will (26:3)

Almuntakhab Fi Tafsir Alquran Alkarim

Seemingly, O Muhammad you are betaking yourself in pursuit of their -the infidels- train of thought with distress, constant regret and discontent and torturing yourself lest they should refuse credit to this divine message

Tafseer Tafheem-ul-Quran by Syed Abu-al-A'la Maududi

(26:3) O Muhammad, you will perhaps consume yourself with grief because these people do not believe. *2

Perhaps, [O Muhammad], you would kill yourself with grief that they will meaning

*2) The words bakhi'un-nafsaka literally mean: "You would kill yourself." The verse in fact describes the extreme anguish, anxiety and grief of the Holy Prophet over the Makkan disbelievers' ways of deviation, moral degradation, and obduracy and opposition to his message of reform. Sometimes it seemed as if his grief and mental suffering for their sake would cause his death. This state of the Holy Prophet has been referred to at other places in the Qur'an as well, for instance in AI-Kahf: 6, thus: "Well, O Muhammad, it may be that you will consume your life for their sake out of sorrow if they do not believe in this message. And in Al-Fatir: 8, thus:" ....Iet not your life be consumed in grief for their sake."
 

Perhaps, [O Muhammad], you would kill yourself with grief that they will meaning in Urdu

اے محمدؐ، شاید تم اس غم میں اپنی جان کھو دو گے کہ یہ لوگ ایمان نہیں لاتے