Those are the ones upon whom the word has come into effect, (46:18)

Almuntakhab Fi Tafsir Alquran Alkarim

Such persons among preceding generations of the Jinn and mankind were born to it; it was their destiny to suffer loss and such destiny has been fulfilled

Tafseer Tafheem-ul-Quran by Syed Abu-al-A'la Maududi

(46:18) It is against such that Allah's sentence (of punishment) has become due. They will join the communities of humans and jinn that have preceded them. Verily all of them will court utter loss. *22

Those are the ones upon whom the word has come into effect, meaning

*22) Here, two types of the character have been placed side by side and the listeners asked the silent question as to which of them is better. At that time both these types of character practically existed in the society, and it was not at aII difficult for the people to know where they could find the first type of the character and where the second. This is the answer to this saying of the chiefs of the Quraish: "If it had been any good to believe in this Book, these few youngsters and slaves would not have believed in it before they did." In the light of this answer everyone could see for himself as to what was the character of the believers and what of the unbelievers.
 

Those are the ones upon whom the word has come into effect, meaning in Urdu

یہ وہ لوگ ہیں جن پر عذاب کا فیصلہ چسپاں ہو چکا ہے اِن سے پہلے جنوں اور انسانوں کے جو ٹولے (اِسی قماش کے) ہو گزرے ہیں اُنہی میں یہ بھی جا شامل ہوں گے بے شک یہ گھاٹے میں رہ جانے والے لوگ ہیں