Those are the ones who will have lost themselves, and lost from (11:21)

Almuntakhab Fi Tafsir Alquran Alkarim

These are they who have lost their own souls and have been forsaken and renounced by those whom they presumed to share with Allah His divine nature, who failed their expectation

Tafseer Tafheem-ul-Quran by Syed Abu-al-A'la Maududi

(11:21) They caused utter loss to themselves, and all that they had invented failed them. *26

Those are the ones who will have lost themselves, and lost from meaning

*26). All their conjectures regarding God, the universe and their own selves will prove to be absolutely baseless in the Next Life. Similarly, the notions they entertained about the help and support they would receive from those they considered to be either their deities, or their intercessors with God, or their patrons will prove to be false. Likewise, it will become obvious that all their notions about the After-life were utterly untrue.
 

Those are the ones who will have lost themselves, and lost from meaning in Urdu

یہ وہ لوگ ہیں جنہوں نے اپنے آپ کو خود گھاٹے میں ڈالا اور وہ سب کچھ ان سے کھویا گیا جو انہوں نے گھڑ رکھا تھا